The smart Trick of ceesdekker.net That Nobody is Discussing
The smart Trick of ceesdekker.net That Nobody is Discussing
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‘Sure, that is about right. I look for a physical comprehension of biological systems inside of a bottom-up way. I believe you could potentially distinguish three traces of analysis in my team in the meanwhile. The very first problems chromosome structure: How does one have a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We've got produced visualisation techniques that let us to study how, such as, SMC proteins loop DNA (video on Youtube) as a way to Construct up chromosomes.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating common and irregular types with recombination purpose.
‘It was simply a make any difference of selecting up a e-book on cell biology and beginning to examine. I had originate from a entire world of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters
We create point-of-treatment diagnostics examination of neglected tropical ailments within useful resource-minimal options, according to Crspr/Cas9 detecting of pathogen’s DNA in body fluids.
Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: speedy electron relay to redox enzymes and zeptomole protein-film voltammetry
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with exploration from DNA supercoiling scientific studies of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his investigate has focused on finding out mobile division with microbes on chip, even though his best curiosity is during the course of noticing synthetic cells.
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Dekker started his investigate on solitary ceesdekker.net carbon nanotubes in 1993 when he setup a new line of exploration to study electrical transportation by means of one organic and natural molecules among nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were being accustomed to reveal that these nanotubes are quantum wires at The only-molecule amount, with exceptional Actual physical Homes.
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
1999, first measurement on the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for just a new Luttinger description of interacting electrons in nanotubes
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements on the DNA molecule inside of a nanopore
Ultimately, I will briefly sketch many of our ideas to discover the constructing of synthetic cells, exclusively our initially ways to determine artificial mobile division.